Marker discovery
Marker discovery
Discovery of markers in all plant species by next-generation sequencing for accelerated plant breeding
The Molecular Genomics group assists in the development of cultivars with superior quality, through practical application of high throughput sequencing and genotyping technologies. The team continuously scouts for novel developments in these fields, and evaluates the most promising of these technologies for application by the shareholder or in shareholder specific applied projects.
The Bioinformatics department at Genetwister applies information technology to the research performed at the company. Within this department, expertise in the fields of molecular biology, information technology, statistics and programming is combined to support gene discovery, breeding, metabolic engineering and diagnostics. An important activity is visualization of data, as this helps other departments and our clients to convert the results into applications. The department has developed tools for analyzing sequencing data, SNP discovery (CROPaware™ software), genome analysis, and analysis of expression data from custom oligoarrays.
The group Genetics and Breeding aims at the advancement of the breeding programs of our shareholders through developing and implementing (marker-assisted) breeding tools. In more detail, the group provides advice on experimental design and phenotyping, performs advanced statistical genetic analysis and facilitates the integration of results in the breeding programs of our shareholders. Our research leads to the identification of the best individuals based on their phenotypic and/or genomic composition. By doing so, we aim at significantly contributing to the the success of our shareholders’ breeding programs.
In the Software Development Group we contribute to the research activities of Genetwister by applying computer science principles and practices. Expert scientists with different backgrounds work together in the design, implementation and maintenance of software tools focused on genomics and breeding data management.
We are an innovative Dutch biotechnology company, with an international position in commercially applied biotechnology of agri- and horticultural crops. Genetwister is your reliable partner in accelerating the breeding of your crop.
Genetwister works to provide cutting edge technologies to five breeding companies to strengthen their leading positions in the field.
Discovery of markers in all plant species by next-generation sequencing for accelerated plant breeding
At Genetwister, tools are developed using distributed computing models and technologies like Spark and Hadoop.
To interconnect different knowledge domains, we use different semantic web technologies.
High parallel computing version of a sequence alignment application.
Appropriate experimental design and data analysis of breeding trials are essential. Genetwister offers assistance in the designing of experiments, taking into account the breeding program’s practical considerations.
Using the state-of-the-art technologies such as long read sequencing technologies, Genetwister is able to build high quality genome assemblies of novel species, and obtain long range genomic information such as haplotypes and structural variants.
Genetwister investigates new methods to integrate phenotypic data into genetic models to support breeding
Genomic selection (GS) is an alternative to marker-assisted selection, which can accelerate the genetic gain through shorter breeding cycles. Genetwister is implementing new breeding schemes and methods that integrate GS for crop improvement.
With the increasing demands for DNA molecule size and purity on the newest long read sequencing platforms, comes the need for developing new protocols for DNA isolation from different biological sources in the laboratory at Genetwister.
Tailored marker selection allowing for genotyping regardless of species, genome size and ploidy level.