The availability of a high-quality reference genome accelerates breeding programs. A reference genome assembled to large scaffolds or even full-length chromosomes reveals the genome architecture as well as locations of specific genes and markers. Insight into gene order allows QTL analyses to be performed without the need of a physical map. Additionally, questions involving structural variant detection can be answered, facilitating prediction of recombination frequencies along the genome. Finally, a good reference genome is a valuable addition to breeding programs involving commercial varieties that lack specific traits that are available in wild germplasm. Back-crossing the genomic regions responsible for these interesting traits is enabled by the availability of a high-quality genome assembly.

Genetwister applies the most recent NGS technologies to construct high-quality reference genomes. These technologies involve long read sequencing combined with genome mapping and chromatin conformation capture data such as Hi-C.

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Other innovations

Long Read Sequencing
Long Read Sequencing

Long Read Sequencing

Using the state-of-the-art technologies such as long read sequencing technologies, Genetwister is able to build high quality genome assemblies of novel species, and obtain long range genomic information such as haplotypes and structural variants.

14 Mar. 2018 View project
High Molecular Weight DNA isolation
High Molecular Weight DNA isolation

High Molecular Weight DNA isolation

With the increasing demands for DNA molecule size and purity on the newest long read sequencing platforms, comes the need for developing new protocols for DNA isolation from different biological sources in the laboratory at Genetwister.

14 Mar. 2018 View project
Semantic Web
Semantic Web

Semantic Web

To interconnect different knowledge domains, we use different semantic web technologies.

14 Mar. 2018 View project
High-throughput sequencing and genotyping
High-throughput sequencing and genotyping

High-throughput sequencing and ...

With increasing sample numbers and marker panel sizes, it is valuable to increase the throughput of sequencing and genotyping procedures. Genetwister develops cost-effective methods and applies available methods for allowing high-throughput genomics.

4 Apr. 2018 View project
Experimental Design
Experimental Design

Experimental Design

Appropriate experimental design and data analysis of breeding trials are essential. Genetwister offers assistance in the designing of experiments, taking into account the breeding program’s practical considerations.

1 Aug. 2018 View project
CROPaware
CROPaware

CROPaware

CROPaware – A web based software platform for breeding and genomics data management.

23 Apr. 2018 View project
Genomic Selection
Genomic Selection

Genomic Selection

Genomic selection (GS) is an alternative to marker-assisted selection, which can accelerate the genetic gain through shorter breeding cycles. Genetwister is implementing new breeding schemes and methods that integrate GS for crop improvement.

14 Mar. 2018 View project
Haplotype discovery
Haplotype discovery

Haplotype discovery

Acceleration and cost reduction in plant breeding with improved genotype/phenotype relations, utilizing linked variants.

14 Mar. 2018 View project