Distributed Analysis Computing

Discovery of markers in all plant species by next-generation sequencing for accelerated plant breeding

Genomic selection (GS) is an alternative to marker-assisted selection, which can accelerate the genetic gain through shorter breeding cycles. Genetwister is implementing new breeding schemes and methods that integrate GS for crop improvement.

Using the state-of-the-art technologies such as long read sequencing technologies, Genetwister is able to build high quality genome assemblies of novel species, and obtain long range genomic information such as haplotypes and structural variants.

With the increasing demands for DNA molecule size and purity on the newest long read sequencing platforms, comes the need for developing new protocols for DNA isolation from different biological sources in the laboratory at Genetwister.

With increasing sample numbers and marker panel sizes, it is valuable to increase the throughput of sequencing and genotyping procedures. Genetwister develops cost-effective methods and applies available methods for allowing high-throughput genomics.

Advanced statistical models are needed to increase the power to discover (new) associations between genetic and phenotypic variation

Tailored marker selection allowing for genotyping regardless of species, genome size and ploidy level.

To interconnect different knowledge domains, we use different semantic web technologies.

Appropriate experimental design and data analysis of breeding trials are essential. Genetwister offers assistance in the designing of experiments, taking into account the breeding program’s practical considerations.

High parallel computing version of a sequence alignment application.