The Genomics team assists in the development of cultivars with superior quality through practical application of high throughput sequencing and genotyping technologies. By staying at the forefront of technological developments in these fields, the team is able to recommend the most promising technologies for application by our shareholders and use them in projects for our customers. We leverage our expertise in molecular and computational biology to make further advancements for improved application in breeding.

Currently, one of the main focus points in the molecular breeding (r)evolution is the increased output and read lengths of next-generation sequencing (NGS) platforms. The Genomics team anticipates on these developments by implementing and optimizing protocols for high throughput DNA isolation and sequence library preparation. The isolation of pure high molecular weight DNA is essential to benefit optimally from the long read lengths of NGS platforms. In addition, we continuously evaluate novel genotyping methods and optimize the throughput and turn-around times of selected workflows and apply them in molecular breeding projects and Genomic Selection programs.

 

Our innovations

Lab automation
Lab automation

Lab automation

With increasing sample numbers comes the need for automating the most valuable and most often applied protocols at Genetwister.

14 Mar. 2021 View project
Experimental Design
Experimental Design

Experimental Design

Appropriate experimental design and data analysis of breeding trials are essential. Genetwister offers assistance in the experimental design, taking into account all practical considerations of the breeding program.

1 Mar. 2021 View project
Genotyping array design
Genotyping array design

Genotyping array design

Tailored marker selection allowing for genotyping regardless of species, genome size and ploidy level.

14 Mar. 2021 View project
Semantic Web
Semantic Web

Semantic Web

To interconnect different knowledge domains, we use different semantic web technologies.

14 Mar. 2021 View project
Association analysis
Association analysis

Association analysis

Advanced statistical models are needed to increase the power to discover (new) associations between genetic and phenotypic variation.

1 Mar. 2021 View project
Haplotype discovery
Haplotype discovery

Haplotype discovery

Acceleration and cost reduction in plant breeding with improved genotype/phenotype relations, utilizing linked variants.

14 Mar. 2021 View project
Long Read Sequencing
Long Read Sequencing

Long Read Sequencing

Using state-of-the-art long read sequencing technologies, Genetwister builds high quality genome assemblies of novel species and obtains long-range genomic information such as haplotypes and structural variants.

14 Mar. 2021 View project