The Molecular Genomics group assists in the development of cultivars with superior quality, through practical application of high throughput sequencing and genotyping technologies. The team continuously scouts for novel developments in these fields and evaluates the most promising of these technologies for application by the shareholder or in shareholder specific applied projects. Currently, one of the main focus points in the molecular breeding (r)evolution is the increased output and read length of sequencing platforms.  The Molecular Genomics group anticipates on these developments by optimizing protocols for high throughput DNA isolation and high throughput sequence library preparation. In addition, the isolation of pure high molecular weight DNA (HMW DNA) is a focus point, as this is essential to benefit optimally from the long read sizes of novel sequencing technologies. In addition, novel genotyping approaches and optimizations in turn-around time are continuously being evaluated for application in, for example, Genomic Selection programs.

Our innovations

High Molecular Weight DNA isolation
High Molecular Weight DNA isolation

High Molecular Weight DNA isolation

With the increasing demands for DNA molecule size and purity on the newest long read sequencing platforms, comes the need for developing new protocols for DNA isolation from different biological sources in the laboratory at Genetwister.

14 Mar. 2018 View project
Genomic Selection
Genomic Selection

Genomic Selection

Genomic selection (GS) is an alternative to marker-assisted selection, which can accelerate the genetic gain through shorter breeding cycles. Genetwister is implementing new breeding schemes and methods that integrate GS for crop improvement.

14 Mar. 2018 View project
Marker discovery
Marker discovery

Marker discovery

Discovery of markers in all plant species by next-generation sequencing for accelerated plant breeding

28 May. 2018 View project
Semantic Web
Semantic Web

Semantic Web

To interconnect different knowledge domains, we use different semantic web technologies.

14 Mar. 2018 View project
CROPaware
CROPaware

CROPaware

CROPaware – A web based software platform for breeding and genomics data management.

23 Apr. 2018 View project
Lab automation
Lab automation

Lab automation

With increasing sample numbers comes the need for automating the most valuable and applied protocols at Genetwister.

14 Mar. 2018 View project
High-throughput sequencing and genotyping
High-throughput sequencing and genotyping

High-throughput sequencing and ...

With increasing sample numbers and marker panel sizes, it is valuable to increase the throughput of sequencing and genotyping procedures. Genetwister develops cost-effective methods and applies available methods for allowing high-throughput genomics.

4 Apr. 2018 View project